TRANSFORMING GROWTH-FACTOR-BETA (TGF-BETA) MESSENGER-RNA EXPRESSION AND GROWTH-CONTROL IN HUMAN LUNG SQUAMOUS CARCINOMA CELL-LINES

Authors
BARTLETT JMS RABIASZ GJ LANGDON SP MILLER EP MILLER WR
Citation
Jms. Bartlett et al., TRANSFORMING GROWTH-FACTOR-BETA (TGF-BETA) MESSENGER-RNA EXPRESSION AND GROWTH-CONTROL IN HUMAN LUNG SQUAMOUS CARCINOMA CELL-LINES, International journal of oncology, 4(2), 1994, pp. 475-479
Citations number
26
Categorie Soggetti
Oncology
Journal title
International journal of oncology → ACNP
ISSN journal
10196439
Volume
4
Issue
2
Year of publication
1994
Pages
475 - 479
Database
ISI
SICI code
1019-6439(1994)4:2<475:TG(MEA>2.0.ZU;2-Z
Abstract
The pattern of TGF-beta mRNA expression and response to TGF-beta isofo rms has been examined in three lung squamous carcinoma cell lines (NX0 02, CX140 and CX143). Expression for TGF-beta1 and TGF-beta2 but not T GF-beta3 was found in all 3 lines. TGF-beta1 and TGF-beta3 (but not TG F-beta2) inhibited the growth of the NX002 cell line in culture. The e ffect of TGF-beta1 on growth was accompanied with changes in the cell cycle. These data indicate that the potential for autocrine regulation by TGF-beta is present in lung squamous carcinoma cells.