Gj. Chandran et al., IMMUNOHISTOCHEMICAL LOCALIZATION OF EPIDERMAL GROWTH-FACTOR AND ITS RECEPTOR IN NORMAL, PREMALIGNANT AND MALIGNANT ORAL-MUCOSA, International journal of oncology, 4(2), 1994, pp. 503-508
An important growth factor involved in epithelial carcinogenesis is th
e epidermal growth factor (EGF). The present study analyze the express
ion pattern of EGF and its receptor (EGFR) in different stages of tumo
ur progression in oral mucosa (normal epithelium, non-dysplastic and d
ysplastic leukoplakias and carcinomas). Alterations in expression patt
ern of EGFR was not significant in the various tissues from normal muc
osa to malignancy. In all these stages EGFR positivity was confined to
the immature basal or basaloid cells. EGF however showed marked alter
ations in expression in different stages of tumour progression in oral
mucosa. Most of the malignant cells were positive for EGF antibodies
while, only a few lower layers of cells were stained in normal mucosa
and in dysplastic leukoplakia lesions, more number of cells expressed
EGF than normal tissue. The present study thus shows the autocrine rol
e of the EGF and EGFR and the possibility of using EGF as a marker for
tumour progression in oral mucosa.