Subdural hematomas are well known but infrequent complications of thro
mbolytic therapy. Although these are usually associated with head trau
ma, the authors describe a case of a patient who received a particular
ly aggressive thrombolytic regimen and presented six months later with
complaints of nothing more than a headache resistant to medical thera
py, without associated neurologic manifestations, which was finally di
agnosed as a chronic subdural hematoma by computerized tomography. In
the era of thrombolysis, physicians should maintain a heightened index
of suspicion for subdural hematoma in patients complaining of headach
e.