EFFECT OF VESICLE SIZE ON THE POLYMERIZATION OF A DIACETYLENE LIPID

Citation
Bm. Peek et al., EFFECT OF VESICLE SIZE ON THE POLYMERIZATION OF A DIACETYLENE LIPID, Macromolecules, 27(1), 1994, pp. 292-297
Citations number
34
Categorie Soggetti
Polymer Sciences
Journal title
ISSN journal
00249297
Volume
27
Issue
1
Year of publication
1994
Pages
292 - 297
Database
ISI
SICI code
0024-9297(1994)27:1<292:EOVSOT>2.0.ZU;2-Q
Abstract
The effect of vesicle size on the photopolymerization products of the polymerizable diacetylene lipid tricosa-10,12-diynoyl)-sn-glycero-3-ph osphocholine (DC8,9PC) has been examined using size exclusion chromato graphy (SEC) and mass spectrometry. Lipid polymers from 50-, 100-, 300 -, and 600-nm vesicles have the same molecular weight range with a pro minent polystyrene equivalent molecular weight peak between 1.6 x 10(6 ) and 2.2 x 10(4). The observed intensity of this peak increased as ve sicle size was increased from 50- through 300-nm diameter, but was dec reased in 600-nm diameter vesicles. After acid catalyzed transesterifi cation of the lipid polymers, the derived acyl chain polymers were exa mined by SEC. These polymers have a common prominent peak correspondin g to a polystyrene equivalent molecular weight between 2.5 X 10(4) and 2.2 x 10(3). Size exclusion chromatography (SEC) and chemical ionizat ion mass spectrometry revealed the presence of the polymerized acyl-ch ain dimer and trimer after methanolysis of the lipid polymer.