IDENTIFICATION AND SYNTHESIS OF A UNIQUE DISULFIDE DIMERIC METABOLITEOF PRIMISULFURON-METHYL IN THE MOUSE

Authors
CAPPS TM HEARD NE SIMMONS DP CONNER CL
Citation
Tm. Capps et al., IDENTIFICATION AND SYNTHESIS OF A UNIQUE DISULFIDE DIMERIC METABOLITEOF PRIMISULFURON-METHYL IN THE MOUSE, Journal of agricultural and food chemistry, 41(12), 1993, pp. 2411-2415
Citations number
5
Categorie Soggetti
Food Science & Tenology",Agriculture,"Chemistry Applied
Journal title
Journal of agricultural and food chemistry → ACNP
ISSN journal
00218561
Volume
41
Issue
12
Year of publication
1993
Pages
2411 - 2415
Database
ISI
SICI code
0021-8561(1993)41:12<2411:IASOAU>2.0.ZU;2-F
Abstract
The major metabolic pathway for primisulfuron-methyl in animals involv es hydroxylation of the pyrimidine ring followed by conjugation. This investigation found a unique metabolite in mice fed at high feeding le vels (>5000 ppm) of the compound. The unique metabolite is identified as a disulfide dimer of the parent compound, and its synthesis is repo rted.