Tm. Capps et al., IDENTIFICATION AND SYNTHESIS OF A UNIQUE DISULFIDE DIMERIC METABOLITEOF PRIMISULFURON-METHYL IN THE MOUSE, Journal of agricultural and food chemistry, 41(12), 1993, pp. 2411-2415
The major metabolic pathway for primisulfuron-methyl in animals involv
es hydroxylation of the pyrimidine ring followed by conjugation. This
investigation found a unique metabolite in mice fed at high feeding le
vels (>5000 ppm) of the compound. The unique metabolite is identified
as a disulfide dimer of the parent compound, and its synthesis is repo
rted.