PHOTODYNAMIC THERAPY-INDUCED ALTERATIONS IN INTERSTITIAL FLUID PRESSURE, VOLUME AND WATER-CONTENT OF AN AMELANOTIC MELANOMA IN THE HAMSTER

Authors
LEUNIG M GOETZ AE GAMARRA F ZETTERER G MESSMER K JAIN RK
Citation
M. Leunig et al., PHOTODYNAMIC THERAPY-INDUCED ALTERATIONS IN INTERSTITIAL FLUID PRESSURE, VOLUME AND WATER-CONTENT OF AN AMELANOTIC MELANOMA IN THE HAMSTER, British Journal of Cancer, 69(1), 1994, pp. 101-103
Citations number
26
Categorie Soggetti
Oncology
Journal title
British Journal of Cancer → ACNP
ISSN journal
00070920
Volume
69
Issue
1
Year of publication
1994
Pages
101 - 103
Database
ISI
SICI code
0007-0920(1994)69:1<101:PTAIIF>2.0.ZU;2-7
Abstract
The effect of photodynamic therapy (PDT) on interstitial fluid pressur e (IFP), tumour volume and water content was measured in melanomas gro wn in hamsters. Unlike control tumours, treated rumours exhibited a 40 -60% increase in volume at 1, 3 and 6 h post PDT. IFP also increased a l 1 and 3 h after PDT, but decreased to 50% of control value after 24 h, presumably as a result of PDT-induced microcirculatory impairment.