COMBINED EVALUATION OF PREOPERATIVE SERUM SIALYL-TN ANTIGEN AND CARCINOEMBRYONIC ANTIGEN LEVELS IS PROGNOSTIC FOR GASTRIC-CANCER PATIENTS

Citation
I. Takahashi et al., COMBINED EVALUATION OF PREOPERATIVE SERUM SIALYL-TN ANTIGEN AND CARCINOEMBRYONIC ANTIGEN LEVELS IS PROGNOSTIC FOR GASTRIC-CANCER PATIENTS, British Journal of Cancer, 69(1), 1994, pp. 163-166
Citations number
23
Categorie Soggetti
Oncology
Journal title
ISSN journal
00070920
Volume
69
Issue
1
Year of publication
1994
Pages
163 - 166
Database
ISI
SICI code
0007-0920(1994)69:1<163:CEOPSS>2.0.ZU;2-Z
Abstract
We have found that elevation of preoperative serum sialyl-Tn antigen ( STN) levels is associated with a poor prognosis for gastric cancer pat ients, and these high levels remain in the advanced stage of the disea se. We have now examined findings with the combined assay of STN and c arcinoembryonic antigen (CEA) levels with regard to prediction of the prognosis of gastric cancer patients. Serum CEA levels and STN levels were determined preoperatively in 349 Japanese patients with gastric c ancer. The patients were divided into four groups: (A) the CEA (-) STN (-) group (CEA less than or equal to 5 ng ml(-1), STN less than or eq ual to 45 U ml(-1), n = 286); (B) the CEA (-) STN (+) group (CEA less than or equal to 5 ng ml(-1), STN> 45 U ml(-1); n = 31); (C) the CEA ( +) STN (-) group (CEA> 5 ng ml(-1), STN less than or equal to 45 U ml( -1), n = 17); and (D) the CEA (+) STN (+) group (CEA> 5 ng ml(-1), STN > 45 U ml(-1), n = 15). Clinicopathological features and the prognosis of these groups were examined. The distribution of two markers showed no significant correlation. The patients in the CEA (+) STN (+) group (group D) had more advanced disease than the patients in CEA (-) STN (-) group (group A); tumour size was larger, serosal invasion was prom inent, lymphatic and vascular involvement was frequent and the tumour was more infiltrative. Lymph node metastasis and hepatic metastasis we re more common. Total gastrectomy was usually performed, and the non-c urative rate was higher. The 5-year survival of patients in the CEA () STN (+) (group D) was 14.5 +/- 9.5%, that is lower than that of pati ents in any other group [CEA (+) STN (-) (group C) 44.1 +/- 12.7% (P<0 .05); CEA (-) STN (+) (group B) 60.1 +/- 9.5% (P>0.05); CEA (-) STN (- ) (group A) 77.6 +/- 9.5% (P<0.05)]. This combined assay of these mark ers will aid in estimating the prognosis and selecting appropriate dru gs and care for gastric cancer patients.