CYCLIC ANALOGS OF CHEMOTACTIC FORMYLPEPTIDES .1. SYNTHESIS AND BIOLOGICAL-ACTIVITY OF FOR-CYS-LEU-PHE-CYS-OME

Authors
ZECCHINI GP PARADISI MP TORRINI I LUCENTE G TRANIELLO S SPISANI S
Citation
Gp. Zecchini et al., CYCLIC ANALOGS OF CHEMOTACTIC FORMYLPEPTIDES .1. SYNTHESIS AND BIOLOGICAL-ACTIVITY OF FOR-CYS-LEU-PHE-CYS-OME, Archiv der pharmazie, 326(12), 1993, pp. 955-958
Citations number
16
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Archiv der pharmazie → ACNP
ISSN journal
03656233
Volume
326
Issue
12
Year of publication
1993
Pages
955 - 958
Database
ISI
SICI code
0365-6233(1993)326:12<955:CAOCF.>2.0.ZU;2-0
Abstract
By using the side chain to side chain mode of cyclization the 14-membe red disulfide cyclopeptide For-Cys-Leu-Phe-Cys-OMe (5) has been synthe sized as conformationally constrained analog of the prototypical chemo tactic tripeptide For-Met-Leu-Phe-OMe. Compound 5 is inactive towards human neutrophils. The lack of biological activity of cyclotetrapeptid e 5 is discussed taking into account the backbone folding and the side chain topography.