Tda. Forbes et al., EFFECTS OF EXOGENOUS AMINES ON REPRODUCTION IN FEMALE ANGORA-GOATS, South African journal of animal science, 23(5-6), 1993, pp. 196-200
An investigation was conducted into the effects of two phenolic amines
, N-methyl-beta-phenethylamine(NMP) and tyramine (T) on corpus luteum
function and reproductive performance of Angora goats. Both compounds
are widely distributed through the plant kingdom and, because of their
sympathomimetic action, may interfere with normal reproductive proces
ses. In Experiment 1, 20 nannies (xBAR = 26.7 +/- 0.96 kg) received ei
ther 0. 1, 2, or 4 mg NMP in 2 ml com oil/kg BW daily, for 45 days. In
Experiment 2, 75 nannies (xBAR = 32.1 +/- 0.46 kg) received either 3,
or 6 mg/kg BW NMP in 2 ml com oil; 1, or 3 mg/kg BW T in physiologica
l saline, or 2 ml corn oil (control) daily, for 45 days. In both studi
es treatments were administered by i.v. injection. Mating was by natur
al service, beginning after the start of treatment. Jugular blood samp
les were collected weekly, processed to yield serum, and serum progest
erone (P4) concentrations were determined by radioimmunoassay (RIA). I
n Experiment 1, no dose response was detected but P4 concentrations we
re reduced (P = 0.03) in the treated animals. In Experiment 2, no dose
response was detected but P4 concentrations in NMP-treated animals (3
.87 +/- 0.618) were lower (P = 0.05) than in the control (5.65 +/- 0.7
47) or in T-treated animals (4.73 +/- 0.528, P = 0.08). No difference
in P4 concentrations was detected between T-treated and control animal
s (P = 0.59). Fewer NMP-treated nannies became pregnant (59%) than eit
her control (77%) or T-treated nannies (88%) (P = 0.053). The results
show that exogenous phenolic amines vary in their effect on reproducti
ve performance of nannies.