INFANTILE SYSTEMIC LUPUS-ERYTHEMATOSUS WITH ONSET SIMULATING CONGENITAL NEPHROTIC SYNDROME

Two white female infants were seen with congenital nephrotic syndrome at age 6 weeks and 3 months, respectively. Both had hypocomplementemia , elevated antinuclear antibody and anti-double-stranded DNA titers, a nd diffuse proliferative glomerulonephritis with positive immunofluore scence in their initial renal biopsy samples. Although uncommon, infan tile systemic lupus erythematosus should be considered in the evaluati on of congenital nephrotic syndrome.