The frequency of RAS and p53 mutations was investigated in 30 acute pr
omyelocytic leukemias by single strand conformation polymorphism analy
sis and direct sequencing of genomic DNA. Only two cases bore N-RAS co
don 12 mutations and none had p53 mutations responsible for aminoacid
substitutions. It would, therefore, seem that neither RAS nor p53 are
involved in acute promyelocytic leukemogenesis.