FREQUENCY OF RAS AND P53 MUTATIONS IN ACUTE PROMYELOCYTIC LEUKEMIAS

Authors
LONGO L TRECCA D BIONDI A LOCOCO F GRIGNANI F MAIOLO AT PELICCI PG NERI A
Citation
L. Longo et al., FREQUENCY OF RAS AND P53 MUTATIONS IN ACUTE PROMYELOCYTIC LEUKEMIAS, Leukemia & lymphoma, 11(5-6), 1993, pp. 405-410
Citations number
NO
Categorie Soggetti
Hematology
Journal title
Leukemia & lymphoma → ACNP
ISSN journal
10428194
Volume
11
Issue
5-6
Year of publication
1993
Pages
405 - 410
Database
ISI
SICI code
1042-8194(1993)11:5-6<405:FORAPM>2.0.ZU;2-T
Abstract
The frequency of RAS and p53 mutations was investigated in 30 acute pr omyelocytic leukemias by single strand conformation polymorphism analy sis and direct sequencing of genomic DNA. Only two cases bore N-RAS co don 12 mutations and none had p53 mutations responsible for aminoacid substitutions. It would, therefore, seem that neither RAS nor p53 are involved in acute promyelocytic leukemogenesis.