CCK-CONTAINING PARANEURONS IN HUMAN ADENOMATOUS PROSTATE

The presence of CCK-containing neuroendocrine cells in human adenomato us prostates, and the colocalization of CCK together with serotonin in the same cell, have been demonstrated by means of an immunohistochemi cal technique and by a double labeling immunofluorescent staining. CCK -containing neuroendocrine cells had a focal distribution in the prost ates and sometimes showed dendrite-like cytoplasmic processes. The maj or part of CCK (96.55%) colocalized with serotonin. CCK probably stimu lates muscle contraction and endocrine/exocrine secretions in the urog enital tract.