CASE OF DOWNS-SYNDROME WITH DIFFUSE LEWY BODY DISEASE AND ALZHEIMERS-DISEASE

Authors
BODHIREDDY S DICKSON DW MATTIACE L WEIDENHEIM KM
Citation
S. Bodhireddy et al., CASE OF DOWNS-SYNDROME WITH DIFFUSE LEWY BODY DISEASE AND ALZHEIMERS-DISEASE, Neurology, 44(1), 1994, pp. 159-161
Citations number
10
Categorie Soggetti
Clinical Neurology
Journal title
Neurology → ACNP
ISSN journal
00283878
Volume
44
Issue
1
Year of publication
1994
Pages
159 - 161
Database
ISI
SICI code
0028-3878(1994)44:1<159:CODWDL>2.0.ZU;2-3
Abstract
Almost all Down's syndrome (DS) patients over the age of 35 to 40 year s have histologic features of Alzheimer's disease (AD). However, the p resence of extrapyramidal features in up to 36% of these patients has no satisfactory pathologic explanation. We report an older patient wit h DS, dementia, and parkinsonian signs who showed pathologic changes o f Parkinson's disease and cortical Lewy bodies in addition to AD. Thes e parkinsonian changes may be related to chromosome 21 abnormalities.