NEW HEXAHYDROXYBIPHENYL DERIVATIVES AS INHIBITORS OF PROTEIN-KINASE-C

Authors
KASHIWADA Y HUANG L BALLAS LM JIANG JB JANZEN WP LEE KH
Citation
Y. Kashiwada et al., NEW HEXAHYDROXYBIPHENYL DERIVATIVES AS INHIBITORS OF PROTEIN-KINASE-C, Journal of medicinal chemistry, 37(1), 1994, pp. 195-200
Citations number
22
Categorie Soggetti
Chemistry Medicinal
Journal title
Journal of medicinal chemistry → ACNP
ISSN journal
00222623
Volume
37
Issue
1
Year of publication
1994
Pages
195 - 200
Database
ISI
SICI code
0022-2623(1994)37:1<195:NHDAIO>2.0.ZU;2-Q
Abstract
We have previously shown that some ellagitannins are potent inhibitors of protein kinase C (PKC). On the basis of this finding, several seri es of hexahydroxybiphenyl derivatives of ellagic acid were synthesized as simple analogs of these ellagitannins and were evaluated for their inhibitory effect against PKC. Compounds 23 and 26 were found to be p otent inhibitors of PKC, while hexakis(benzyloxy)biphenyl derivatives exhibited weak anti-PKC activity.