DOPAMINE BLOCKS T-TYPE CALCIUM CHANNELS IN CULTURED RAT ADRENAL GLOMERULOSA CELLS

Authors
OSIPENKO ON VARNAI P MIKE A SPAT A VIZI ES
Citation
On. Osipenko et al., DOPAMINE BLOCKS T-TYPE CALCIUM CHANNELS IN CULTURED RAT ADRENAL GLOMERULOSA CELLS, Endocrinology, 134(1), 1994, pp. 511-514
Citations number
26
Categorie Soggetti
Endocrynology & Metabolism
Journal title
Endocrinology → ACNP
ISSN journal
00137227
Volume
134
Issue
1
Year of publication
1994
Pages
511 - 514
Database
ISI
SICI code
0013-7227(1994)134:1<511:DBTCCI>2.0.ZU;2-3
Abstract
Dopamine is known to inhibit aldosterone secretion. In the present stu dy using whole-cell voltage-clamp technique we found that dopamine, br omocriptine and quinpirole inhibit low-threshold (T-type) voltage depe ndent Ca2+ channels. The inhibition was sustained and reversible, and it was prevented by sulpiride. These findings indicate that the effect of dopamine was mediated via DA2 receptors.