THE METHYLATION OF BOLDINE WITH DIAZOMETHANE

Authors
ASENCIO M CASSELS BK SPEISKY H
Citation
M. Asencio et al., THE METHYLATION OF BOLDINE WITH DIAZOMETHANE, Boletin de la Sociedad Chilena de Quimica, 38(4), 1993, pp. 331-334
Citations number
6
Categorie Soggetti
Chemistry
Journal title
Boletin de la Sociedad Chilena de Quimica → ACNP
ISSN journal
03661644
Volume
38
Issue
4
Year of publication
1993
Pages
331 - 334
Database
ISI
SICI code
0366-1644(1993)38:4<331:TMOBWD>2.0.ZU;2-0
Abstract
A preliminary kinetic study of the methylation of boldine with diazome thane to afford glaucine, based on H-1-NMR spectra recorded at differe nt times, showed that this reaction proceeds via both N-methyllaurotet anine (2-O-methylboldine) and predicentrine (9-O-methylboldine). Methy lation at the 9-O-position is faster and consequently, at stages in wh ich most of the precursor has been consumed, only predicentrine and gl aucine accumulate in isolable amounts.