A CASE OF CENTRAL DIABETES-INSIPIDUS WITH SPONTANEOUS REMISSION AFTER8 YEARS OF THE DISEASE

A 55-year-old male smoker developed polyuria and polydipsia in Novembe r 1983. A water deprivation study revealed a defect in the urine conce ntrating function, which was corrected by vasopressin. Plasma antidiur etic hormone (ADH) was not increased by smoking. His condition was wel l controlled by deamino-D-arginine vasopressin. However, since Februar y 1992 he has become completely free from the need for medication to c ontrol his urine volume. Re-evaluation studies with water deprivation smoking revealed dramatic improvements in the urine concentrating func tion and ADH response. A patient with idiopathic diabetes insipidus wi th spontaneous remission after 8 years is reported.