EXTENDING THE USE OF GONADOTROPIN-RELEASING-HORMONE AGONISTS - THE EMERGING ROLE OF STEROIDAL AND NONSTEROIDAL AGENTS

Objective: To review and summarize the state of the art as it relates to the long-term application of GnRH agonists (GnRH-a). Design: A retr ospective analysis of the available literature and results and an up-t o-date review of a rapidly evolving field. Conclusion: Although the pr ecise use of long-term GnRH-a therapy (in conjunction with sex steroid add-back therapy) remains unknown, the information provided strongly supports additional studies in this area to achieve a body of promisin g preliminary data.