The transsphenoidal approach to the pituitary (TSA) is currently the m
ost common approach used to treat pituitary tumors. The surgical techn
ique necessitates an incomplete stripping of sphenoid sinus mucosa. Lo
ng-term postoperative magnetic resonance imaging (MRI) evaluation of t
he sphenoid sinus has not been reported. A retrospective review of pat
ients undergoing a TSA at the University of Washington Hospitals was p
erformed. Preoperative scans were compared with postoperative scans do
ne during three time intervals. Group 1 had scans at 1 to 12 weeks pos
toperatively; 10 of 10 patients had sinus effusions. Group 2 had scans
at 6 to 18 months postoperatively; 22 of 31 had mucosal abnormalities
. Group 3 had scans at 2 to 3 years; 7 of 9 were abnormal. MRI evaluat
ion indicates that a majority of patients have both acute and chronic
sphenoid sinus abnormalities after TSA.