Recent epidemiological studies have consistently shown that panic diso
rder, according to DSM-III, occurs in adults with a lifetime prevalenc
e of about 2% and a 6-month prevalence of about 1.2%. Panic attacks ar
e relatively common, with a lifetime rate of about 9%. Being female an
d divorced and separated is associated with higher prevalence of panic
disorder. The hazard rates for panic disorder were highest between th
e ages of 25 and 34 years for females and between the ages of 30 and 4
4 years for males. Panic disorder frequently co-occurs with other anxi
ety disorders as well as with a wide range of mental disorders such as
depression and substance use disorder. Based on few epidemiological s
tudies, panic disorder has been found to have a chronic course with ra
re complete remission. Subjects with panic disorder were at an increas
ed risk of social impairment, not getting along with their partners, a
s well as being financially dependent, and were likely to report fair
or poor global physical health, and emotional health. Cases with panic
disorder had the most severe psychosocial impairment and the worst ou
tcome as compared to other anxiety disorders. Moreover, they are high
users of all types of medical services, including mental health and ge
neral medical providers. Although recent epidemiological data, with it
s improved methodology, have considerably increased our knowledge conc
erning panic attack, panic disorder and agoraphobia, there are still m
ajor questions concerning the etiology, natural history, prevention, o
r control of panic disorder that need to be answered. Furthermore, sin
ce panic disorder has been considered as developing in stages, our cur
rent epidemiological knowledge cannot tell us in sufficient detail abo
ut the specific role of suggested risk factors in the development of p
anic disorder through its various stages.