PYRIDINE AND PYRIMIDINE RING SYNTHESES FROM 4-(4-MORPHOLINO)-3-PENTENONE AND FROM ETHYL 3-(4-MORPHOLINO)-2-BUTENOATE

Authors
RATEMI ES NAMDEV N GIBSON MS
Citation
Es. Ratemi et al., PYRIDINE AND PYRIMIDINE RING SYNTHESES FROM 4-(4-MORPHOLINO)-3-PENTENONE AND FROM ETHYL 3-(4-MORPHOLINO)-2-BUTENOATE, Journal of heterocyclic chemistry, 30(6), 1993, pp. 1513-1516
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
30
Issue
6
Year of publication
1993
Pages
1513 - 1516
Database
ISI
SICI code
0022-152X(1993)30:6<1513:PAPRSF>2.0.ZU;2-Y
Abstract
3-Substituted 2(1H)-pyridones are produced from reaction of 4-(4-morph olino)-3-pentenone 1 with each of the following carbon acids: cyanoace tamide, malononitrile, cyanothioacetamide, acetylacetamide, benzoylace tonitrile. Reaction of ethyl 3-(4-morpholino)-2-butenoate 2 with cyano acetamide gives the corresponding hydroxypyridone. Pyrimidines are for med by reaction of 1 and of 2 with benzamidine and with S-benzylthio-u rea; in the last case, the eliminated morpholine displaces the benzylt hio group to give the final product.