THE ONCOEPIDEMIOLOGIC INVESTIGATION UNDER CHEMICAL CARCINOGENS REGULATION

Methodological approaches to the organization of epidemiological inves tigation concerned with hygienic regulation of chemical carcinogens ar e presented. The main aspects are illustrated by the epidemiological s tudy of the effects of carcinogenic polycyclic aromatic hydrocarbons, in particular, benz(a)pyrene, on the incidence of lung cancer among th e population. The correlation between aerogenic exposure of the carcin ogens to the population in a number of cities and rural regions of Ukr aine and the incidence of lung cancer is shown. Concentrations of the carcinogens inducing a statistical reliable risk of increase of lung c ancer morbidity in population were established by using mathematical m odelling. The reliability of atmospheric air maximal permissible conce ntration (MPC) for benz(a)pyrene (1.0 ng/c. m.), according to the onco epidemiological index, is tested.