THE INTEGRAL CHARACTERISTIC OF C57BL 6 MI CE IMMUNE-SYSTEM UNDER MYELOPIDUM ACTION ON THE GRAFTED B16 MELANOMA DEVELOPMENT/

The essential structural parameters of immune processes in C57BL/6 mic e bearing B16 melanoma have been investigated by the morphometrical me thod. The integral characteristic of the immune system under myelopidu m action on tumorigenesis at the latent, settling and progression stag es is given. Activity of the T-cellular system is characterized by lym phocyte generation and cellularity in the thymus and T-zones of the ly mph nodes as well as by the generation/death ratio. Activity of the B- cellular system is characterized by the size of the germinal centres a nd spleen plasmocyte zones, composition of the plasmacyte pool in the lymph nodes. The ratio of activities of T-cellular to B-cellular syste ms has been analyzed as well. The possibility of myelopidum clinical a pplication at early stages of tumorigenesis when antitumour immunity i s enhanced by the drug is shown. The authors substantiate the danger o f the myelopidum treatment during the tumor progress when the T-cell a ctivity peak is changed by severe deficiency, which in combination wit h continuous activation of the B-cellular system aggravates the unfavo urable prognosis.