Vv. Kravchuk et al., THE EFFECT OF ENTEROSORBENTS ON THE FUNCT ION OF THE LIVER MONOOXYGENASE SYSTEM IN PATIENTS WITH OVARIAN-CANCER DURING CHEMOTHERAPY, Eksperimental'naa onkologia, 15(5), 1993, pp. 61-64
The effect of polymer based enterosorbents with active functional grou
ps on the cytochrome P-450-dependent monooxygenase system of the liver
was studied in patients with ovarian cancer (III-IV stage) during che
motherapy. It was established that the enterosorbents reduced the toxi
c effect of antitumour drugs and enhanced the liver antitoxic function
, which was expressed in a significant (practically two-fold) decrease
of half-life time of antipyrine in patients.