ANTITUMOR-ACTIVITY OF FREE AND LIPOSOME-E NCAPSULATED PLAXANT IN A HEMICE WITH HA-1 TUMOR-METASTASES IN THE LIVER/

Authors
KALEDIN VI POPOVA NA STETSENKO AI YAKOVLEV KI
Citation
Vi. Kaledin et al., ANTITUMOR-ACTIVITY OF FREE AND LIPOSOME-E NCAPSULATED PLAXANT IN A HEMICE WITH HA-1 TUMOR-METASTASES IN THE LIVER/, Eksperimental'naa onkologia, 15(5), 1993, pp. 75-77
Citations number
7
Categorie Soggetti
Oncology
Journal title
Eksperimental'naa onkologia → ACNP
ISSN journal
02043564
Volume
15
Issue
5
Year of publication
1993
Pages
75 - 77
Database
ISI
SICI code
0204-3564(1993)15:5<75:AOFALN>2.0.ZU;2-1
Abstract
Plaxant, a new platinum compound injected intravenously (iv) of mice w ith HA-1 tumour metastases in the liver in a dose of 360 mg/kg gave ri se to 35.7 % lethality caused by general toxicity and prolonged the li fe span of the other mice by 61.9 % as compared to the control. Fracti onal intraperitoneal administration of free plaxant had no advantages as compared to iv injection. The same dose of plaxant encapsulated in liposomes after iv administration caused no lethality but increased th e life span of mice by 91.5 %.