A Tc-99m bone scan of a patient with classic roentgenographic findings
of osteopoikilosis revealed multiple foci of increased activity that
corresponded to many of the sclerotic foci on the roentgenograms. The
authors presume that the abnormal bone scan in this patient reflects a
ctive osseous remodeling, similar to what has been observed in bone is
lands. Previous reports have emphasized the critical role of the radio
nuclide bone scan for distinguishing osteopoikilosis from osteoblastic
bone metastases in patients with a known or suspected primary maligna
ncy. In a young patient, an abnormal bone scan does not exclude the di
agnosis of osteopoikilosis if the roentgenographic findings are charac
teristic of that entity.