SYNTHESIS OF MURAMYL DIPEPTIDE CONJUGATED WITH ACRIDINE-DERIVATIVES, SHOWING ANTI-HIV-1 AND ANTICANCER ACTIVITY

Authors
DZIERZBICKA K KOLODZIEJCZYK AM WYSOCKASKRZELA B KOLODZIEJCZYK AS
Citation
K. Dzierzbicka et al., SYNTHESIS OF MURAMYL DIPEPTIDE CONJUGATED WITH ACRIDINE-DERIVATIVES, SHOWING ANTI-HIV-1 AND ANTICANCER ACTIVITY, Polish Journal of Chemistry, 68(1), 1994, pp. 37-45
Citations number
22
Categorie Soggetti
Chemistry
Journal title
Polish Journal of Chemistry → ACNP
ISSN journal
01375083
Volume
68
Issue
1
Year of publication
1994
Pages
37 - 45
Database
ISI
SICI code
0137-5083(1994)68:1<37:SOMDCW>2.0.ZU;2-X
Abstract
A series of analogues of N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) conjugated at position 6 of the carbohydrate residue with some acridi ne derivatives were synthesized as potential anti-HIV-1 and/or antican cer agents. Preliminary screening data indicate that some of them (4a, 4d and 3e) exhibit anti-HIV-1 activity and some others, including the most active compound 3c, act as antitumor agents.