CONDUCTOMETRIC TITRATION AND GAS-CHROMATOGRAPHIC ANALYSIS OF KETOPROFEN SALTS IN PHARMACEUTICAL FORMULATIONS

Two methods for the analysis of ketoprofen salts (lysine and sodium sa lts), both in the pure products and in pharmaceutical formulations are presented: they are based respectively on conductivity measurements a nd on gas-chromatography. In the first case, the method calls for a ti tration in aqueous medium of ketoprofen salts by means of standard 5.6 x 10(-3) mol/l HCl solutions. Both accuracy and precision were found to be quite satisfactory and did not seem to be sensitive to the prese nce of the common excipients found in commercial pharmaceutical formul ations. The second method entails programmed-temperature analysis of t he methyl ester of ketoprofen in the presence of an internal standard. In this case accuracy and precision remain high, but the results are affected by the presence of excipients.