E. Doyle et al., PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING WITH TRANSDERMAL HYOSCINE IN CHILDREN USING PATIENT-CONTROLLED ANALGESIA, British Journal of Anaesthesia, 72(1), 1994, pp. 72-76
We have studied 40 children aged 6-14 yr undergoing abdominal surgery
under general anaesthesia with extradural block; they were allocated r
andomly to receive transdermal hyoscine (loading dose 140 mu g, follow
ed by 5 mu g h(-1)) or placebo for the duration of postoperative analg
esia with PCA morphine. There was a significant (P < 0.001) reduction
in She incidence of postoperative nausea and vomiting in the treated g
roup compared with the placebo group during the first 48 h after opera
tion. The treated group also had a significantly increased incidence o
f sedation (P < 0.02) and dry mouth (P < 0.01).