CARBAMAZEPINE POISONING - PROTRACTED COUR SE WITH DEVELOPMENT OF GASTROINTESTINAL ATONY AND HEPATOTOXICITY

Authors
BAISCHER W WAGNER A SEIDLER D MUSALEK M LAGGNER A
Citation
W. Baischer et al., CARBAMAZEPINE POISONING - PROTRACTED COUR SE WITH DEVELOPMENT OF GASTROINTESTINAL ATONY AND HEPATOTOXICITY, Wiener Klinische Wochenschrift, 106(1), 1994, pp. 27-29
Citations number
7
Categorie Soggetti
Medicine, General & Internal
Journal title
Wiener Klinische Wochenschrift → ACNP
ISSN journal
00435325
Volume
106
Issue
1
Year of publication
1994
Pages
27 - 29
Database
ISI
SICI code
0043-5325(1994)106:1<27:CP-PCS>2.0.ZU;2-9
Abstract
A 43 year-old female patient with a history of manic-depressive illnes s and prophylactic carbamazepine (CBZ) medication ingested a potential ly lethal overdose of 20 g of the substance. Neurotoxic symptoms reach ed full intensity after about 24 hours. Subsequently, the patient deve loped a gastrointestinal atony, which proved to be refractory to treat ment for several days. Moreover, there was an increase of bilirubin. P arallel to this we observed the persistence - and even intermittent re -increase - of toxic serum CBZ concentrations for one week with corres ponding protracted clinical symptomatology.