Important advances in the treatment of eating disorders, particularly
bulimia nervosa, have been made during the past decade. Controlled tri
als for bulimia nervosa have demonstrated significant benefit from sho
rt-term pharmacotherapy with antidepressant medications and from short
-term individual and group psychotherapies. Despite these advances, tr
eatment of a patient often involves complex clinical decisions around
such issues as choice of initial treatment modality, incomplete resolu
tion of symptoms, and the role of long-term maintenance treatment. To
address these questions, this review focuses primarily on summarizing
results of published controlled trials of pharmacotherapy in patients
with bulimia nervosa. In addition, it outlines the more limited litera
ture on controlled pharmacotherapy trials for anorexia nervosa and for
the provisionally identified syndrome of binge eating disorder.