A PHASE-II TRIAL OF CARBOPLATIN AND VINDESINE IN PATIENTS WITH NON-SMALL-CELL LUNG-CANCER - A HELLENIC-COOPERATIVE-ONCOLOGY-GROUP STUDY

In an effort to investigate a regimen less toxic and more convenient t han cisplatin combinations, 50 patients with non-small cell lung cance r (NSCLC) were treated in a Phase 11 study with carboplatin and vindes ine. Carboplatin 300 mg/m2 every 28 days and vindesine 3 mg/m2 every 2 weeks were administered on an outpatient basis. Eight patients had a partial response of their disease (16%, confidence limits 7-29%). Mean duration of response was 4.5+ months (1 +/- 8). Toxicity, mainly of g rade I-II, was noticed in 4-28% of the patients. The most common side effect was mild to moderate leukopenia (28%). The combination of carbo platin and vindesine at the above doses was very well tolerated. Altho ugh the response rate was relatively low, the survival in this patient population was similar to other cisplatin-containing regimens.