Ke. Uhrich et al., IN-VITRO DEGRADATION CHARACTERISTICS OF POLY(ANHYDRIDE-IMIDES) CONTAINING TRIMELLITYLIMIDOGLYCINE, Journal of applied polymer science, 63(11), 1997, pp. 1401-1411
The in vitro degradation characteristics of poly(anhydride-imides) con
taining trimellitylimidoglycine, with either 1,6-bis(carboxyphenoxy)he
xane or sebacic acid, were assessed. The copolymers contained 10, 30,
or 50 mol% of the imide monomer, trimellitylimidoglycine. Degradation
was pH-sensitive, being enhanced under basic conditions. Control of de
gradation times from 1 day to 2 months was achieved by the selection o
f appropriate monomer units in the polymer backbone. Monomers were cho
sen based on their solubility in aqueous media, as well as how they in
fluenced the hydrophobicity of the polymer matrices. Increasing the am
ount of imide monomer, trimellitylimidoglycine, and the use of sebacic
acid rather than 1,6-bis(carboxyphenoxy)hexane as the comonomer incre
ased the degradation rate of the polymer matrices. (C) 1997 John Wiley
& Sons, Inc.