JUMPING TRANSLOCATIONS OF 1Q IN BURKITT-LYMPHOMA AND ACUTE NONLYMPHOCYTIC LEUKEMIA

''Jumping translocations'' have been observed mostly in cultured cells . Reports of such translocations in hematologic malignancies are few, and the associated clinical picture is unclear. We report three cases of hematologic malignancies with various unbalanced translocations (so -called jumping translocation) involving trisomy of the long arm of ch romosome 1. The first case was a 13-year-old boy with Burkitt lymphoma who showed a very aggressive clinical course. The second case was a 1 0-month-old girl with acute nonlymphocytic leukemia (ANNL, French-Amer ican-British (FAB) classification Mo) who had high risk factors, inclu ding hyperleukocytosis with a peripheral white blood cell (WBC) count of 300,000/mu l, and who died 7 months after diagnosis. The third case was a g-year-old boy with Burkitt-like leukemia whose first remission lasted only 1 month. Only 10 cases with jumping translocations, inclu ding two cases with Burkitt-like leukemia/lymphoma, have been reported previously. This rare phenomenon may occur with increased frequency i n Burkitt-like leukemia/lymphoma and may be an adverse prognostic fact or.