CONFORMATIONALLY RESTRICTED PETHIDINE ANA LOGS .5. SYNTHESIS AND PHARMACOLOGICAL EXAMINATION OF CIS-B-B-10-ACYL-1,2,3,4,4A,5,6,10B-OCTAHYDROBENZO [F]ISOQUINOLINES

Authors
REIMANN E BENEND HD HOFNER G
Citation
E. Reimann et al., CONFORMATIONALLY RESTRICTED PETHIDINE ANA LOGS .5. SYNTHESIS AND PHARMACOLOGICAL EXAMINATION OF CIS-B-B-10-ACYL-1,2,3,4,4A,5,6,10B-OCTAHYDROBENZO [F]ISOQUINOLINES, Die Pharmazie, 48(12), 1993, pp. 890-893
Citations number
6
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
48
Issue
12
Year of publication
1993
Pages
890 - 893
Database
ISI
SICI code
0031-7144(1993)48:12<890:CRPAL.>2.0.ZU;2-C
Abstract
Cyanophenylcyclobuten (1 a) gave the corresponding cis-B-configurated 10b-acyloctahydrobenzo[fl isoquinolines 3a-f by Grignard reaction. Cis -B-3b was demethylated to yield the secondary base 3g, which in turn w as realkylated to the homologous allyl- and isopentenyl derivatives 3h and 3i. In the writing test the desoxyketobemidon analogon cis-B-3b e xhibits a remarkable activity, whereas 3a, c-e are somewhat weaker and 3h and 3i are inactive.