SYNTHESIS OF CARBOHYDRATES VIA TANDEM USE OF THE OSMIUM-CATALYZED ASYMMETRIC DIHYDROXYLATION AND ENZYME-CATALYZED ALDOL ADDITION-REACTIONS

Authors
HENDERSON I SHARPLESS KB WONG CH
Citation
I. Henderson et al., SYNTHESIS OF CARBOHYDRATES VIA TANDEM USE OF THE OSMIUM-CATALYZED ASYMMETRIC DIHYDROXYLATION AND ENZYME-CATALYZED ALDOL ADDITION-REACTIONS, Journal of the American Chemical Society, 116(2), 1994, pp. 558-561
Citations number
22
Categorie Soggetti
Chemistry
Journal title
Journal of the American Chemical Society → ACNP
ISSN journal
00027863
Volume
116
Issue
2
Year of publication
1994
Pages
558 - 561
Database
ISI
SICI code
0002-7863(1994)116:2<558:SOCVTU>2.0.ZU;2-J
Abstract
A new strategy is described for the asymmetric synthesis of carbohydra te derivatives via the tandem use of the osmium-catalyzed asymmetric d ihydroxylation (AD) and aldolase-catalyzed aldol addition reactions. B oth D- and L-forms of fructose, 6-deoxy-galacto-2-heptulose, and 6-phe nyl-galacto-2-hexulose were synthesized to illustrate this methodology .