S. Krupp et al., MIDTERM RESULTS WITH CULTURED EPIDERMAL AUTOGRAFTS, ALLOGENIC SKIN TRANSPLANTS AND CYCLOSPORINE-A MEDICATION, Burns, 20(1), 1994, pp. 15-20
Citations number
NO
Categorie Soggetti
Dermatology & Venereal Diseases","Emergency Medicine & Critical Care
Transplantation of allogenic split thickness skin grafts (STSG) and im
munosuppression with cyclosporin A enable early and definitive skin re
placement of extensive, deep partial and full thickness burns. Coverin
g burn defects with definitely engrafted, allogenic dermis and cultiva
ted epithelial autografts (CEA) permits the subsequent withdrawal of c
yclosporin A medication. Light-microscopy examination of biopsies, tak
en 12 and 24 months postgrafting, and electron microscopy of biopsies
taken 12 months postgrafting, demonstrates a re-established, but somew
hat reduced anchoring of the CEA as compared with a normal epidermal-d
ermal junction. Clinical inspection, 20 months postgrafting, confirms
the histological observations that epifascial transplantation is quali
tatively inferior to placing the allogenic STSG on the subcutaneous ti
ssue. In the first situation, the dermis is inelastic and collagen dep
osition is excessive, whereas in the second case collagen deposition i
s comparatively reduced and the dermis shows clinically some elasticit
y.