Dermal dendrocytes constitute the largest population among cells of de
rmatofibromas. In other histiocytic tumours, the exact nature of histi
ocytic cells is not known. We have searched for the presence of dermal
dendrocytes in juvenile xanthogranulomas. The immunohistochemical stu
dy was performed on 9 juvenile xanthogranulomas. We used monoclonal or
polyclonal antibodies: anti-XIIIa, HAM56, anti-S100, anti-NSE, anti-H
LA-DR, anti-CD68 and anti-lysozyme. Phagocytic mononuclear cells (hist
iocytes, giant cells, Touton cells) did not express Langerhans' cell m
arkers (S100, NSE ou HLA-DR). They weakly expressed markers of macroph
ages (CD68, lysozyme). There was a very strong binding by HAM56 and an
ti-XIIIa. This expression was more evident on xanthomatous and newly a
ppeared tumours than on fibrous tumours. The largest population of juv
enile xanthogranuloma cells appeared to be constituted by dermal dendr
ocytes. These cells are perhaps the key-cells of a continuum of benign
tumours, from juvenile xanthogranuloma to dermatofibroma, with differ
ent stages corresponding to different proportions of dendrocytes, lymp
hocytes and fibroblasts.