Fifty-four eyes of 45 patients with ocular hypertension developed earl
y glaucomatous optic disc or visual field changes after a mean follow-
up of 5.1 years without therapy. These changes initiated antiglaucomat
ous treatment, and the eyes have been followed further on therapy for
2-14 years (mean 8.0 years) in a retrospective study. The mean intraoc
ular pressure (IOP) was lowered from 28.9 to 19.3 mmHg. Half of the ey
es were still without field defects at the end of the study, whereas 7
eyes developed extensive field damage noticeable to the patients. The
eyes with deteriorating visual fields could not be differentiated fro
m the stable ones by means of the pre-therapy IOP, nor the mean or pea
k IOP on treatment. There was an accumulation of topical and general r
isk factors in the progressive eyes. The results support the importanc
e of taking other risk factors than the IOP into consideration in the
management of our glaucoma patients.