Choroidal malign melanoma showing rapid progression in a boy 17 years
old is presented. The patient was under therapy with methoxy psoralen
+ Ultraviolet A (PUVA) for psoriasis vulgaris. He had undergone compl
ete ophthalmologic examinations with three-month intervals from the be
ginning of this therapy. The tumor was detected in the seventh month,
rapidly enlarging within the next twenty days, and eventually leading
to enucleation. PUVA is known to be a risk factor for cutaneous malign
melanoma. However, there is no reported incidence of choroidal malign
melanoma in PUVA treated patients. To our knowledge, this is the only
case showing the possible role of PUVA therapy as a predisposing fact
or in the development of uveal malign melanoma.