RAPID METHOD FOR ISOLATING TARGETED ORGANIC-CHEMICALS FROM BIOLOGICALMATRICES

The initial development is reported for a novel countercurrent filtrat ion/dialysis and solid phase extractant system for the rapid isolation of low molecular weight target compounds from biological media. Excep t for piperazine (a highly water-soluble drug), recoveries of 50 - 85% were achieved for chemical warfare agent simulants and anthelmintic d rugs extracted from meat, grain, or milk. The results suggest the pote ntial for broad applications to complex samples such as environmental media and physiological specimens which traditionally require extensiv e fractionation prior to analysis.