In order to assess the accuracy of pulse oximeters in patients with se
ptic shock, we compared 80 paired readings of oxygen saturations taken
from pulse oximeters and oxygen saturations obtained from co-oximetry
in patients receiving intensive therapy with indwelling pulmonary art
ery flotation catheters. Comparison between groups with low or normal
systemic vascular resistance indices showed a small (1.4%) but signifi
cant (p < 0.001) underreading of the saturation from the pulse oximete
r in the presence of a low systemic vascular resistance. With normal o
r high systemic vascular resistance pulse oximeter readings correlated
well with co-oximetry. We hypothesise that the main cause of this und
erreading is because the pulse oximeter is sensing pulsatile venous fl
ow due to the opening of arteriovenous channels in the skin in septic
states.