Thirty-five patients who had undergone uncomplicated cardiac surgery w
ere randomly allocated to receive either Entonox or isoflurane 0.25% i
n Entonox as inhalational analgesia for the removal of their two chest
drains. The gases were presented premixed in high-pressure cylinders
and were self-administered by means of a demand valve. The removal of
the second drain was more painful than the first but that pain was bet
ter controlled by isoflurane 0.25% in Entonox than by Entonox alone.