SYNTHETIC STUDIES OF HALICHONDRIN-B, AN ANTITUMOR POLYETHER MACROLIDEISOLATED FROM A MARINE SPONGE .4. SYNTHESIS OF THE C37-C54 SUBUNIT VIA STEREOSELECTIVE CONSTRUCTION OF 3 CONSECUTIVE J-RING, K-RING, AND L-RING

Authors
HORITA K SAKURAI Y NAGASAWA M MAENO K HACHIYA S YONEMITSU O
Citation
K. Horita et al., SYNTHETIC STUDIES OF HALICHONDRIN-B, AN ANTITUMOR POLYETHER MACROLIDEISOLATED FROM A MARINE SPONGE .4. SYNTHESIS OF THE C37-C54 SUBUNIT VIA STEREOSELECTIVE CONSTRUCTION OF 3 CONSECUTIVE J-RING, K-RING, AND L-RING, Synlett, (1), 1994, pp. 46-48
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
1
Year of publication
1994
Pages
46 - 48
Database
ISI
SICI code
0936-5214(1994):1<46:SSOHAA>2.0.ZU;2-K
Abstract
A stereoselective synthesis of the C37-C54 subunit of halichondrin B v ia coupling between the C38-C43 fragment starting from D-tartaric acid and the C44-C54 fragment strating from L-tartaric acid is reported. C onstruction of three consecutive J, K, and L rings and introduction of asymmetric centers at C51 and C53 were important steps.