SELECTIVE ENZYMATIC DEPROTECTION OF HYDROXY-GROUP AND AMINO-GROUP IN CARBOHYDRATES AND NUCLEOSIDES

Authors
WALDMANN H HEUSER A REIDEL A
Citation
H. Waldmann et al., SELECTIVE ENZYMATIC DEPROTECTION OF HYDROXY-GROUP AND AMINO-GROUP IN CARBOHYDRATES AND NUCLEOSIDES, Synlett, (1), 1994, pp. 65-67
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
1
Year of publication
1994
Pages
65 - 67
Database
ISI
SICI code
0936-5214(1994):1<65:SEDOHA>2.0.ZU;2-3
Abstract
The enzyme acetyl esterase from the flavedo of oranges (EC 3.1.1.6) ch emo- and regioselectively removes acetyl groups from carbohydrates and nucleosides. The chemoselective enzymatic liberation of the amino fun ctions present in the nucleobases of O-acetylated nucleosides is achie ved by penicillin G acylase (EC 3.5.1.11) mediated hydrolysis of the c orresponding phenylacetamides.