A SYNTHETIC APPROACH TO THE C26-C32 FRAGMENT OF RAPAMYCIN - A SYNTHESIS OF ALLYLIC ALCOHOLS FROM ALLYLIC FURYLSILANES

Authors
NORLEY MC KOCIENSKI PJ FALLER A
Citation
Mc. Norley et al., A SYNTHETIC APPROACH TO THE C26-C32 FRAGMENT OF RAPAMYCIN - A SYNTHESIS OF ALLYLIC ALCOHOLS FROM ALLYLIC FURYLSILANES, Synlett, (1), 1994, pp. 77-78
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
1
Year of publication
1994
Pages
77 - 78
Database
ISI
SICI code
0936-5214(1994):1<77:ASATTC>2.0.ZU;2-I
Abstract
Key steps in a synthesis of the C23-C32 fragment of rapamycin include a regioselective Pd(0)-catalysed silylstannylation of an alkyne; a Pd( 0)-catalysed coupling of a (Z)-2-silyl-1-stannylalkene with an acid ch oride; and a Fleming-Tamao oxidation of an allylic silanol generated b y photo-oxidation of an allylic furyldimethylsilane.