MULTIPLE-SCLEROSIS - ASSESSMENT OF COLONIC AND ANORECTAL FUNCTION IN THE PRESENCE OF FECAL INCONTINENCE

Six females suffering from Multiple Sclerosis (MS) with symptoms of co nstipation and faecal incontinence were investigated using anal manome try, proctometrogram proctography and large bowel transit time estimat es (using inert markers). Results were compared to a control group (4 females, 2 males). Resting anal sphincter pressure (internal sphincter function) was reduced, but not significantly so, compared with contro ls (46+/-12.6 vs. 68+/-8.2 mmHg: P<0.1). Maximum squeeze increment pre ssure (external sphincter function) was significantly diminished in th e patient group (13.5+/-4.5 vs. 82.5+/-12.3 mmHg: P<0.0001). Radiologi cal imaging of the anorectum demonstrated an abnormal position of the pelvic floor at rest, with moderate descent in most cases during strai ning. Measurement of anorectal angles (puborectalis muscle function) i ndicated a normal angle at rest (76+/-10.4 degrees), but with little c hange on maximum contraction (74+/-3.5 degrees) and on straining (79+/ -4.6 degrees). Rectal sensory parameters did not differ from controls either for minimum sensation, 44.5+/-5.2 vs. 30+/-5.8 ml (P<0.1), or a t maximum tolerable volume, 163+/-34.5 vs. 148+/-22 ml (P>0.2). Four o f six patients failed to empty 100% of simulated stool at proctography , at which the only anatomical defect was the presence of a rectocele in two patients. Large bowel transit studies revealed abnormally slow transit in 82% of patients, all of whom had delay in the distal colon. These physiological studies demonstrate that in patients with MS who had anorectal dysfunction, there is a marked impairment of external an al sphincter function with moderate changes in pelvic floor musculatur e. Delayed distal colonic transit may be associated with inability to completely evacuate the rectum.