F. Deponti et al., CALCIUM-CHANNEL BLOCKERS AND GASTROINTESTINAL MOTILITY - BASIC AND CLINICAL ASPECTS, Pharmacology & therapeutics, 60(1), 1993, pp. 121-148
Several calcium-channel blockers currently in use for the treatment of
cardiovascular disorders have recently been tested for their effects
on gastrointestinal motility. The rationale for this approach centers
on the concept that calcium-channel blockers are at least as potent in
inhibiting intestinal smooth muscle as in relaxing vascular smooth mu
scle. This review will give an outline of the most recent findings on
the role of calcium and calcium channels in smooth muscle and neuronal
function in the digestive system. It will also consider the mechanism
s by which calcium-channel blockers may affect gastrointestinal motili
ty and assess potential clinical applications in gastroenterology. The
main goal for researchers in this field will be the development of gu
t-selective agents, with no cardiovascular side effects.