A NOVEL NUCLEAR RECEPTOR SUPERFAMILY MEMBER IN XENOPUS THAT ASSOCIATES WITH RXR, AND SHARES EXTENSIVE SEQUENCE SIMILARITY TO THE MAMMALIAN VITAMIN-D3 RECEPTOR

Authors
SMITH DP MASON CS JONES EA OLD RW
Citation
Dp. Smith et al., A NOVEL NUCLEAR RECEPTOR SUPERFAMILY MEMBER IN XENOPUS THAT ASSOCIATES WITH RXR, AND SHARES EXTENSIVE SEQUENCE SIMILARITY TO THE MAMMALIAN VITAMIN-D3 RECEPTOR, Nucleic acids research, 22(1), 1994, pp. 66-71
Citations number
39
Categorie Soggetti
Biology
Journal title
Nucleic acids research → ACNP
ISSN journal
03051048
Volume
22
Issue
1
Year of publication
1994
Pages
66 - 71
Database
ISI
SICI code
0305-1048(1994)22:1<66:ANNRSM>2.0.ZU;2-4
Abstract
We report the isolation of xONR1, a novel member of the nuclear recept or superfamily from Xenopus laevis. xONR1 shares a high degree of amin o acid sequence identity with the mammalian receptor for 1 alpha, 25-d ihydroxy vitamin D3, particularly within the DNA-binding domain, altho ugh it does not bind this ligand. xONR1 DNA binding is stimulated by a ssociation with retinoid X receptor gamma (RXR gamma).