Immunosensors can directly transduce biological reactions into electri
cal signals using paired electrodes one or both coated with the immuno
reactant, thus enabling substances to be analyzed directly or indirect
ly. This analytical procedure detects the first stage of agglutination
, the sensitization of cells, and eliminates the necessity of evaluati
ng the second stage, agglutination, and all of its variables. Positive
reactions for blood group determinations can be detected within 30 se
conds. A method using electronic data transfer, for determination of r
ed cell antigen-antibody interaction, is imminent.